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Unisom review: can these products help you get a good night’s sleep?



Unisom review

Unisom is a range of non prescription sleep aids that help you drift off into a restful sleep both quickly and easily.

Their formulas are non habit forming and contain a mix of antihistamines and natural ingredients to support deep sleep without any drowsiness.

Our Unisom review looks at the benefits and ingredients associated with Unisom products, to see if it is a good solution for a silent night.


What is Unisom?

Unisom is a range of sleep aids that help people with mild insomnia to get to sleep.

How does Unisom work?

Unisom uses sleep inducing ingredients to fool the brain and body into relaxation and sleep.  

Who should use Unisom?

Unisom should be used by anyone who is struggling to get adequate sleep and feels they could use some gentle help drifting off.

How much does Unisom cost?

The price ranges from $6.99 to $29.00 depending on the formula and pack size.

Is Unisom a fad?

No, Unisom is a clinically backed sleep aid.

Is Unisom safe?

Unisom is safe for use if you follow the directions and do not exceed the stated dose. However, do not take this product before driving or operating machinery.

Where to buy Unisom?

Unisom can be purchased from Amazon, Walmart, and various drugstores.

Does Unisom really work?

Yes, the ingredients in Unisom are proven to help you fall asleep and wake up feeling refreshed.

Are there any Unisom alternatives?

There are many other sleep aids available on the market. Some examples are ‘Nytol’ and ‘Sominex’


Unisom includes a range of products containing non habit forming drugs and natural ingredients.

These are clinically proven to relax the body and mind, encouraging you to fall asleep quickly and stay asleep until morning.  

Their range includes non prescription tablets, gels, melting strips, pain relief formulas and immune support formulas. All of these products have the same main goal though; encouraging the body to get some quality sleep and to stay healthy.

If you are suffering from a lack of shut eye, Unisom can provide the following sleep related benefits:

Promotes Sleep

Sleep can be interpreted as: a condition of body and mind which typically recurs for several hours every night, in which the nervous system is inactive.’ (1)

This definition can make sleep sound as if it isn’t really very important, but studies have shown sleep is crucial for our overall health and wellbeing. (2)

Unisom uses a variety of antihistamines and natural hormones to promote healthy sleep.

Improves Mood

Not getting enough sleep can negatively affect our moods.

Those who get inadequate amounts of sleep over a period of time often start to suffer from low moods. This can then become a vicious cycle because low moods can also be a cause of insomnia. (3)

Unisom includes ingredients that help to lift the mood as well as help you drift off to sleep.

Supports Memory

Getting the correct amount of sleep can help protect against cognitive decline.

When you are tired, you have probably noticed how your mind feels ‘foggy’ and you cannot process or recall information as quickly as you normally can.

However, if you are chronically sleep deprived this puts you at risk of long term damage to your memory. (4)

By ensuring you get enough sleep Unisom can help you have a clear head the next day and also protect your memory.

Manages Hunger

Not getting enough sleep can lead to weight gain and is also a contributor to obesity. This is because a sleep deprived body requires more energy to function.

Our brain stimulates feelings of hunger when we haven’t had enough sleep and we often crave sugary snacks for an energy hit. This is because sleep ‘starvation’ increases the hunger hormone ‘ghrelin’ whilst reducing satiety hormone ‘leptin’. (5)

As a result, chronic sleep loss has been shown to lead to weight gain. (6)

Supports Immune System

It is a recognised fact lack of sleep has detrimental effects on the efficiency of our immune system. Clinical studies have found if people do not get a good night’s sleep, they are putting themselves at risk of falling sick due to immune suppression. (7)

When we are sleeping, our body releases proteins which help promote sleep and fight against infection. These proteins are known as called cytokines. (8)

If we are not getting enough rest, we do not release enough cytokines and this decreases our immune responses.

Unisom products not only help promote sleep, they also contain ingredients which help to support the immune system and decrease your chance of falling sick.


Unisom has a range of products with differing ingredients. However, they all produce the same general effect, helping you sleep. The following ingredients are found in their products:

Doxylamine Succinate

Doxylamine succinate is the active ingredient in Unisom sleeptabs.

It is a type of antihistamine which has sedative effects.

Antihistamines make us feel sleepy due to the manner in which they interact with histamines, these are naturally produced within our bodies.

Histamines are chemical compounds and part of our natural immune response to foreign substances. They also regulate our sleeping patterns.

If we break our skin and injure ourselves, the immune system immediately sends white blood cells to the area which release histamines in response. These histamines search for other cells with a suitable receptor so they can bind together.

This means histamines work by creating inflammation in the area, expanding blood vessels to increase the flow of blood to the locality and promote healing. (9)

Histamine is also responsible for regulating our circadian rhythm, which tells us when to wake up and fall asleep. (10)

Not enough histamine can make us feel very sleepy, while too much histamine keeps us awake.

Antihistamines prevent histamines from attaching to their receptors, stopping them from doing their jobs. It is for this reason we feel drowsy and sleepy after taking them. (11)


Diphenhydramine is the active ingredient in Unisom sleepgels.

It is also an antihistamine, so promotes sleep in the same way as doxylamine succinate.


Melatonin is an ingredient in Unisom immune support tablets.

Melatonin is a hormone manufactured by our brains pineal gland.

It is sometimes referred to as the body’s ‘hormone of darkness’ because it plays a critical role in promoting sleepiness. It works by signalling to the body it’s evening time and this is when we should be winding down to sleep for the night. (12)

Melatonin interacts with receptors responsible for a feeling of relaxation. It also decreases the levels of a wakefulness hormone known as dopamine. (13,14)

It is no surprise low levels of melatonin result in a struggle to fall asleep. By supplementing with melatonin before bed, you naturally encourage sleep without any the need for other drugs.

Acetaminophen (PM Pain)

Acetaminophen is an ingredient in Unisom PM pain tablets.

It acts as a painkiller and can also reduce feverishness.

When injure ourselves, the body releases pain messengers called ‘prostaglandins’. Acetaminophen works to diminish pain by blocking the manufacture of the messengers responsible for these signals. (15)

This means it helps you to get a restful and pain free sleep.

Vitamin B6

Vitamin B6 is included in the Unisom immune support formula.

Tryptophan is a kind of amino acid with a role in promoting relaxation and sleepiness. (16)

Vitamin B6 can convert some of this amino acid into another beneficial neurotransmitter for sleep, ‘serotonin’. (17,18)

If we do not get enough vitamin B6 from our food, we can unbalance the levels of tryptophan and therefore serotonin in our body. This will result in a greater risk of insomnia and restlessness.

Another benefit of vitamin B6 is the manner in which it supports the mood.

Depressive moods are often a cause of sleep problems, whilst being chronically tired can also cause depression. (19)

A deficiency in vitamin B6 is believed to contribute to feelings of depression and low mood.

Therefore supplementing with vitamin B6 can help you to feel both uplifted and better able to fall asleep


Echinacea is an ingredient in Unisom immune support.

Echinacea is a flower native to North America and is a popular natural remedy for colds and flu.

It has anti inflammatory and antiviral benefits, is a powerful antioxidant and it can also provide support for the immune system. (20,21)

Side Effects

Both doxylamine succinate and diphenhydramine can cause some potential side effects. These can manifest as: constipation, stomach upsets, dizziness, drowsiness, dry eyes, blurred vision, a loss of balance and a dry feeling in the nose and throat.

Acetaminophen can sometimes result in a severe skin rash which can require immediate medical attention.

Aside from this it can cause itching, stomach pains, loss of appetite, nausea, discoloured stools, yellow eyes or skin and dark urine. It is best to stop taking this product if you experience any of these symptoms.

Recommended Dosage

For all the formulations, the recommended dosage is one capsule a short time before you go to bed.


Unisom is a range of sleep aids available without prescription.

The formula varies slightly between the different products to provide additional benefits depending upon your needs.

We like how there is a good choice available, including easy swallow gels and melt tabs. This means there is something for everyone to ensure you stay rested and healthy.

It is also very encouraging to see these products are not habit forming, so you can use them to get a good night’s rest as needed and without worrying about any dependency issues.

Overall, we believe Unisom is a great choice for people who are struggling to get adequate sleep and do not want to go down the route of prescription medication.

Attention Unisom readers: Click here for our #1 rated sleep aid

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