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Protandim review: does it really fight the signs of aging?



Protandim ReviewProtandim is a two part anti-aging supplement that works to prevent the body from aging while also repairing the body from any existing damage.

The formula is based upon scientific theory surrounding the links between the aging process, energy cell function and boosting antioxidants. The notion being these two factors can slow it down and reverse damage.

In this review, the science behind this supplement will be examined to see if Protandim truly has the anti-aging effects it promises.


What is Protandim?

Protandim is a two part supplement using ingredients specially formulated to reverse the effects of aging in the body. It provides the body with fuel to repair damage at a cellular level and reduces stress.

How does Protandim work?

Protandim works by reversing any damage in the body caused by oxidative stress, a major factor in the aging process. It is a system of two supplements, NRF1 and NRF2 and together they work to repair and rejuvenate the body and prevent aging.

Who should use Protandim?

Anyone above the age of 18 years can use Protandim. However it is not suitable for pregnant or nursing women. It is also important to consult a physician before starting any supplement regime if on regular medication for a pre-existing health condition.

How much does Protandim cost?

The two-part system of Protandim, which includes the NRF1 and NRF2 supplements, retails at $102.99 per month. A monthly subscription is possible for a discounted price of $85.99. Both NRF1 and NRF2 can also be purchased separately.

Is Protandim a fad?

Fad diets and supplements are characterized by promises which have minimal scientific support in their efficacy. Protandim has numerous studies to back its chosen ingredients.  

Is Protandim safe?

Yes, Protandim is safe to use as directed. However, it’s important to consult a physician before starting any supplement program.

Where to buy Protandim?

Protandim is available to purchase directly from the official website.

Does Protandim really work?

Based on scientific studies, the research supports it claims as an anti-aging supplement. However, each individual can experience different results.

Are there any Protandim alternatives?

There are other similarly based anti-aging products available such as Elysium by Basis and Serovital.  


Protandim works to stop the body from aging by using two supplements in conjunction with each other to make a “super” fuel.

Energy Production

When youth starts to pass us by, joints begin to ache, knees hurt on the stairs and the brain starts to feel a little less sharp.

This is mainly down to as the body ages, mitochondria (cell energy center) loses ability to produce an important substance called adenosine triphosphate (ATP). ATP is the fuel that provides energy to the heart, muscles and supports the brain. (1)

Without mitochondria making this fuel, the body takes longer to recover and energy is reduced. (2)

NFR1 can improve performance through energy production. It can enhance cellular health by helping cells function at their peak capacity.

It also increases cellular energy and boosts mitochondria production. (3)

Healing Oxidative Stress

Oxidative stress can be described as the knock on effect of having more damaging free radicals than beneficial antioxidants within the body. This type of biological warfare can have a devastating impact on your health, it leads to many different diseases including cancer.  (4)

Oxidative stress is also linked to alzheimer’s disease, memory loss and other degenerative disorders. (5)

NRF2 can apparently reduce oxidative stress by 40% in just 30 days. It significantly reduces cellular stress and produces digestive enzymes which are able to neutralize more than one million free radicals.

It can also regulate survival genes, help the body rejuvenate its own cells and detoxify genes.  


Oxidative stress is also a big part of aging. The buildup of free radicals and toxins in the body results in stress on the cells and a breakdown of the body at cellular level. (6)

Protandim stops the aging process by providing the mitochondria with important fuel. It sends messages to cells to continue regeneration.

It contains a powerful formula of ingredients designed to work together to stop the aging process and repair damage which has already occured.


There are two different formulas within the Protandim system of which both contain five different ingredients specific to their traits.

Protandim NRF1

Protandim NRF1 is the first part of this dual-action supplement. It targets the NRF1 pathways in the cell, sending the body a message to generate mitochondrial compounds and replace any which have been lost. (7)

The ingredients include:

Coenzyme Q10

Coenzyme Q10 is an enzyme responsible for producing energy in the cells. As people age, they often lack this vital compound. (8)

It reduces oxidative stress in the body and can lower the risk of heart failure by fighting the effects of aging. (9)

Alpha-Lipoic Acid

Alpha-Lipoic Acid is an acid which works in the body as a supportive mood stabilizer. It has been shown in research to combat depression. ( 10)

It also can reduce the effects of cortisol in the brain. Cortisol is a stress hormone responsible for the fight-or-flight response which can cause premature aging and contribute to symptoms of depression. (11)

By lowering cortisol it prevents the body from aging because of stress caused from an active lifestyle. (12)

Grape Extract

Made from the entire grape, this ingredient contains the natural polyphenols which support the body in fighting the aging process.

Polyphenols reduce inflammation and hold antioxidant properties while assisting the body in repairing cell damage. (13)


Quercetin is a powerful antioxidant which can help to reduce oxidative stress in the body. It is found naturally in a number of fruits and vegetables, including grapes, nuts, onions, apple and black tea. (14)

This potent compound also has many other benefits, including: anti-inflammatory, anticarcinogenic, antiviral, psychostimulant, cardioprotective, neuroprotective, antipathogenic and immune regulatory properties. (15)


Acetyl-l-carnitine is an amino acid which promotes energy production in the body. It transports fatty acids into the mitochondria of cells in order to use the fatty acids as energy.

It also transports waste out of the mitochondria, therefore it supports healthy cells and energy. Without it, the body ages quickly because it is unable to keep the mitochondria working properly. (16)

Protandim NRF2 Synergizer

Protandim NRF2 Synergizer works to repair the body from aging. Its ingredients are formulated to reduce oxidative stress and combat the effects of aging caused by damage that may have already occured. (17)

It also boosts antioxidants in the body, repairs damaged cells and neutralizes free radicals. (18)

The ingredients include the following:


Ashwagandha has been used for years in natural medicine.

Research has shown promise for this adaptogenic herb in preventing cognitive diseases, such as alzheimer’s and promoting memory. (19, 20)

Green Tea

Green tea has been praised for its health benefits for years. There is evidence it can support cognition, brain function and healthy weight.

It has also shown to support cardiovascular health and lower risk of stroke. Containing a rich source of antioxidants, it has properties that may reduce the risk of cancer and encourage weight loss. (21)

Green tea supports an alert mind and brain because it contains levels of caffeine. (22)

Milk Thistle

A powerful botanical medicine, milk thistle can work to prevent fatty liver disease and support mitochondria (energy producer) in the body. (23)

It works to reverse oxidative stress on a cellular level and also combat aging. (24)

Bacopa Monnieri

Bacopa monnieri is a plant effective for lowering anxiety, depression and memory loss.

It is neuroprotective and contains antioxidants which support both the liver and the brain by neutralizing free radicals. (25)


Turmeric as a healthy spice which has gained in popularity. There are numerous ways it can be incorporated into the diet and has been used to treat a variety of ailments. (26)

It has both antioxidant and reparative properties, neutralizing free radicals and reducing inflammation. It can also prevent neurotoxic damage. (27)

Side Effects

There are no reported side effects for Protandim, however some ingredients such as coenzyme Q10, quercetin, acetyl-L-carnitine, ashwagandha and bacopa monnieri can cause reactions on an individual basis.

These include: dizziness, nausea, upset stomach, irritability, and insomnia.  

Protandim is also not suitable for anyone who is nursing, pregnant or undergoing immunosuppressive therapy.

Recommended Dosage

Protandim is a two part supplement designed to work together to repair the body.

The recommended dosage is as follows: 2 capsules of NRF1 per day and 1 capsule of NRF2 per day.  These should all be taken in the morning with food.


Protandim is an anti-aging supplement that works by repairing the body from any existing damage whilst also slowing down the aging process. It provides a formula designed to fuel the mitochondria, which in-turn supports the heart, brain and body.

Protandim includes ingredients backed by science to reverse the aging process and repair oxidative stress. Based on research, Protandim appears to have the ability to do what it promises.

However, although evidence promising it’s important to remember, we all react differently towards supplements therefore some will benefit more than others.

That said, even if your objective is to boost energy levels, your mental performance or top up antioxidants in the body, Protandim stands you in good stead for achieving these goals.

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